刘秀梅 博士 / 副教授

硕士生导师 生物科学专业教师

2026年01月 - 至        今：烟台大学，生命科学学院，副教授

2018年07月 - 2025年12月：烟台大学，生命科学学院，讲师

2013年09月 - 2018年06月：中国海洋大学, 海洋生命学院, 理学博士

2009年09月 - 2013年06月：中国海洋大学, 海洋生命学院, 理学学士

●主讲课程

本科生：《分析化学》、《海洋生物学》、《人体生理学》

研究生：《海洋生物技术》、《现代生态学》

● 研究方向

海洋动物遗传育种与健康养殖。

● 教学、科研项目

[1] 国家自然科学基金青年项目，30万元，2026.01-2028.12，在研，主持。

[2] 一种牡蛎养殖用可调节的附苗装置，150万元，2025.08-2027.08，在研，主持。

[3] 扇贝新品种（系）营养成分检测及群体遗传分析，6.8万元，结题，主持。

[4] 三倍体长牡蛎鳃对溶藻弧菌的免疫响应，3万元，结题，主持。

[5] 烟台大学青年博士科研启动基金项目，8万元，2019-2024，结题，主持。

● 主要论文、专著与专利

主要论文

第一或通讯作者论文

[1] Liu X^#, Yang J^#, Wang W, Bao X, Chang D, Hao Z, Qiu M, Liu Y, Teng X and Li Z (2025). Mechanisms of nanoplastic-induced energy metabolism reprogramming in juvenile Sepia esculenta: mRNA profile, miRNA/mRNA network, and ceRNA network. Environmental Chemistry and Ecotoxicology, 7:1836-1849. (#共同第一作者)

[2] Liu X, Zhao Y, Zhang J, Zhang E, Feng Y, Li Z, Wang W and Yang J (2025). Molecular mechanisms of infertility in male triploid pacific oysters (Crassostrea gigas). Aquaculture Reports, 44:103074.

[3] Liu X^#, Wang W^#, Zhao H, Wang Y, Jiang L, Zhang E, Feng Y, Wang X, Qu J, Yang J and Li Z (2025). Transcriptome profiling of triploid Crassostrea gigas gills indicates the host immune mechanism against bacterial infection. Comparative Biochemistry and Physiology - Part D: Genomics and Proteomics, 54:101392. (#共同第一作者)

[4] Liu X^#, Zhao Y^#, Han K, Cui C, Feng Y, Sun G, Xu X, Wang Q, Li Z Wang W and Yang J (2025). Comprehensive physiological and transcriptomic profiling of triploid pacific oysters (Crassostrea gigas) under ammonia exposure. Biology (Basel), 14,1121. (#共同第一作者)

[5] Zhao Y, Chang D, Zheng Y, Zhang Y, Wang Y, Bao X, Sun G, Feng Y, Li Z^…, Liu X^… and Yang J^… (2025). Comparative transcriptome analysis reveals differences in immune responses to copper ions in Sepia esculenta under high temperature conditions. BMC Genomics, 26:262. (…共同通讯作者)

[6] Liu X^#, Li Z^#, Li Q, Bao X, Jiang L and Yang J (2024). Acute exposure to polystyrene nanoplastics induced oxidative stress in Sepia esculenta larvae. Aquaculture Reports, 35:102004. (#共同第一作者)

[7] Wang Y^#, Liu X^#, Wang W, Sun G, Feng Y, Xu X, Li B, Luo Q, Li Y, Yang J, Cui C and Li Z (2024). The investigation on stress mechanisms of Sepia esculenta larvae in the context of global warming and ocean acidification. Aquaculture Reports, 36:102120. (#共同第一作者)

[8] Wang Y^#, Liu X^#, Lv T, Wang W, Sun G, Yang J and Li Z (2024). Investigating the impact of ocean acidification on anti-stress mechanisms in Sepia esculenta larvae based on transcriptome profiling. Journal of Ocean University of China, 23(4):1054-1066. (#共同第一作者)

[9] Liu X, Bao X, Wang X, Li C, Yang J and Li Z (2023). Time-dependent immune injury induced by short-term exposure to nanoplastics in the Sepia esculenta larvae. Fish and Shellfish Immunology, 132:108477.

[10] Liu X, Bao X, Yang J, Zhu X and Li Z (2023). Preliminary study on toxicological mechanism of golden cuttlefish (Sepia esculenta) larvae exposed to cd. BMC Genomics, 24:503.

[11] Liu X, Bao X, Qian G, Wang X, Yang J and Li Z (2023). Acute effects of polystyrene nanoplastics on the immune response in Sepia esculenta larvae. Aquatic Toxicology, 258:106478.

[12] Liu X, Yang J and Li Z (2023). Transcriptomic analysis of oxidative stress mechanisms induced by acute nanoplastic exposure in Sepia esculenta larvae. Frontiers in Physiology, 14:1250513.

[13] Liu X, Bao X, Li Z and Zhang Q (2023). Investigation of gene networks in three components of immune system provides novel insights into immune response mechanisms against Edwardsiella tarda infection in Paralichthys olivaceus. Animals, 13, 2542.

[14] Liu X, Li Z, Yan W, Zhao H, Liu Y, Han M, Wang X, He Y, Yu H and Zhang Q (2022). GATA4 is a transcriptional regulator of SOX2 in Japanese flounder (Paralichthys olivaceus). Journal of Ocean University of China, 21(1): 163-170.

参与发表论文

[1] Zhu X, Wang W, Wang Y, Zhao Y, Bao X, Cui C, Xu X, Liu X, Yang J and Li Z (2026). Mitigative effects and associated regulatory responses of selenium-enriched yeast against ammonia exposure in triploid Pacific oysters (Crassostrea gigas). Aquaculture, 626:744370.

[2] Lu C, Han P, Xue Y, Liu X, Chen J and Wang X (2026). Identification of PI3K gene family in large yellow croaker (Larimichthys crocea): Expression patterns under Pseudomonas plecoglossicida infection and hypoxia stress, and functional verification of pik3r3b. Fish and Shellfish Immunology, 171:111199.

[3] Han P, Yuan M, Sun Z, Xue Y, Liu X, Chen J, Yu H and Wang X (2025). Effect of heat exposure on histology, transcriptomics and co-expression network: A synthetic study in Japanese flounder (Paralichthys olivaceus). Aquaculture, 595:741490.

[4] Han P, Xue Y, Sun Z, Liu X, Miao L, Yuan M and Wang X (2025). The toxicological effects of perfluorooctanoic acid (PFOA) exposure in large yellow croaker (Larimichthys crocea): exploring the relationship between liver damage and gut microbiota dysbiosis. Environmental Research, 278:121683.

[5] Han P, Yan W, Liu X and Wang X (2024). Differential environmental-induced heat stresses cause the structural and molecular changes in the spleen of Japanese flounder (Paralichthys olivaceus). Aquaculture, 581:740490.

[6] Wang R, Liu X, Han Q and Wang X (2023). Characterisation, evolution and expression analysis of the interferon regulatory factor (IRF) family from olive flounder (Paralichthys olivaceus) in response to Edwardsiella tarda infection and temperature stress. Fish and Shellfish Immunology, 142:109115.

专利

[1]刘秀梅，李赞，王卫军，杨建敏，曲江勇，王绪敏.一种牡蛎养殖用可调节的附苗装置,中国.

[2] 刘秀梅，李赞，王卫军，杨建敏，曲江勇，王绪敏.一种牡蛎分拣机,中国.

● 荣誉奖励

烟台市“D类人才”

● 学术兼职

[1]期刊Agriculture Communications、Biological Diversity和《淡水渔业》青年编委。

[2]2025年度“中国水产学会科学传播专家团队”——“水产养殖种质资源保护利用科学传播专家团队”成员。

[3] Aquaculture, Fish and Shellfish Immunology、Food Chemistry等10余本SCI期刊审稿人。

● 联系方式

通信地址：山东省烟台市莱山区清泉路30号，烟台大学生命科学学院

邮编：264005

Email：liuxiumei@ytu.edu.cn