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纪海玉 副教授/硕士生导师 ●出生年月 1990年1月 ●工作经历 2022年06月~至今：烟台大学生命科学学院，助理研究员、讲师、副教授 2020年07月~2022年06月：天津科技大学生物工程学院，轻工技术与工程科研流动站，制糖工程专业，博士后，助理研究员 ●学习经历 2017年09月~2020年06月：天津科技大学食品科学与工程学院，食品科学，博士 2015年05月~2017年07月：天津科技大学食品科学与工程学院，科研助理 2012年09月~2015年03月：天津科技大学食品科学与工程学院，食品科学，硕士 2008年09月~2012年07月：山西农业大学食品科学与工程学院，生物工程，学士 ●主讲课程 本科生课程：《食品毒理学（含实验部分）》、《食品免疫学》、《食品工厂设计与环境保护》 研究生课程：《食品生物工程》 ● 研究方向 主要聚焦天然产物与功能食品开发领域，核心研究方向包括： 1. 天然活性物质的高效制备工艺研发与优化 2. 天然活性物质的免疫调节构效关系及作用机制评价 3. 基于天然活性物质的功能性食品配方设计与开发 ● 教学、科研项目 [1] 肉苁蓉鲜切加工与精准营养食品开发及产业化 [2] 药食同源免疫制剂开发 [3] 溶剂电位对龙须菜琼胶多糖结构表征及成膜特性的影响机制研究 [4] 天然白芨多糖基保鲜材料的可控构建及其在桃果实保鲜中的应用 [5] 基于免疫系统干预肿瘤生长相关制剂的开发 [6] 基于线上线下混合式智慧教学的《食品毒理学》教学改革与实践 ● 主要论文 [1] Fan Yu-Ting, Ji Hong-Fei, Han Xiao, Dong Xiao-Dan, Ding Wen-Jie, Yu Juan, Peng Li-Zeng, Ji Hai-Yu*. Structural characteristics and intestinal immunity of Codonopsis pilosula polysaccharides prepared by electrolytic water [J]. Industrial Crops and Products, 2025, 307:121794. [2] Fan Yu-Ting, Yang Chen-Qi, Zhao Yi-Ran, Han Xiao, Ji Hong-Fei, Ren Zhuo-hao, Ding Wen-Jie, Ji Hai-Yu*. Regulatory effects of Codonopsis pilosula alkali-extracted polysaccharide induced intestinal lactobacillus enrichment on peripheral blood proteomics in tumor-bearing mice [J]. Microorganisms, 2025, 13(8):1750. [3] Gong You-Shun, Guo Na-Lin, Dai Ke-Yao, Han Bing, Wang Zhen-Hua, Ji Hai-Yu*. Primary structure analysis of cold water-soluble alcohol extract from green tea and the regulatory effects on intestinal flora metabolism [J]. LWT-Food Science and Technology, 2025, 216, 117313. [4] Ji Hong-Fei, Li Mei, Han Xiao, Fan Yu-Ting, Yang Jia-Jing, Long Yan, Yu Juan, Ji Hai-Yu*. Lactobacilli-mediated regulation of the microbial-immune axis: a review of key mechanisms, influencing factors, and application prospects [J]. Foods, 2025, 14(10): 101763. [5] Ji Hong-Fei, Li Mei, Wang Ru-Xue, Mao De-Cheng, Ji Zhuo-Yang, Peng Li-Zeng, Ding Wen-Jie, Ji Hai-Yu*. Study on the enrichment effect of Suillus luteus polysaccharide on intestinal probiotics and the immunomodulatory activity [J]. Microorganisms, 2025, 14(1):4. [6] Long Yan, Yang Jia-Jing, Ji Hong-Fei, Fan Yu-Ting, Dai Ke-Yao, Ding Wen-Jie, Ji Hai-Yu*, Yu Juan. Gut microbiota mediated immunoregulatory effects of Dendrobium officinale polysaccharides-selenium nanoparticles complexes [J]. Food Bioscience, 2025, 69: 107033. [7] Dai Ke-Yao, Ding Wen-Jie, Li Zhen-Tong, Liu Chao, Ji Hai-Yu*, Liu An-Jun. Comparison of structural characteristics and anti-tumor activity of two alkali extracted peach gum arabinogalactan [J]. International Journal of Biological Macromolecules, 2024, 279: 135407. [8] Dai Ke-Yao, Liu Chao, Ji Hai-Yu*, Liu An-Jun. Extraction, structural identification and anti-tumor activity of two Cordyceps militaris polysaccharides evaluated by S180 tumor-bearing mice [J]. Industrial Crops and Products, 2024, 210: 118163. [9] Dai Ke-Yao, Wang Ruo-Han, Mu Lan, Ji Hai-Yu*, Liu An-Jun. Structural characteristics and anti-tumor activity of alcohol-precipitated polysaccharides from Cordyceps militaris under different ethanol concentrations [J]. International Journal of Biological Macromolecules, 2024, 278: 134784. [10] Dong Xiao-Dan, Sun Su-Jun, Wang Xin-Kun, Yu Huan-Jie, Dai Ke-Yao, Jiao Jian-Shuang, Peng Chun-e, Ji Hai-Yu*, Peng Li-Zeng. Structural characteristics and intestinal flora metabolism mediated immunoregulatory effects of Lactarius deliciosus polysaccharide [J]. International Journal of Biological Macromolecules, 2024, 278: 135063. [11] Ding Wen-Jie, Huo Yao, Li Zhen-Tong, Liu Yan-Ru, Dai Ke-Yao, Liu Chao, Ji Hai-Yu*, Liu An-Jun. A macromolecular Gleditsia saponin induces apoptosis of leukemia cells through fas-mediated death receptor pathway and mitochondrial pathway [J]. Food Bioscience, 2024, 59: 104146-. [12] Gao Xiao-Ji, Fan Yu-Ting, Dai Ke-Yao, Zheng Guo-Qiang, Jia Xiao-Yu, Han Bing, Xu Bo, Ji Hai-Yu*. Structural characterization of an acid-extracted polysaccharide from Suillus luteus and the regulatory effects on intestinal flora metabolism in tumor-bearing mice [J]. International Journal of Biological Macromolecules, 2024, 280, 136137. [13] Huo Yao, Ding Wen-Jie, Liu Yan-Ru, Li Zhen-Tong, Dai Ke-Yao, Liu Chao, Ji Hai-Yu*, Liu An-Jun. Selenochemical modification of low molecular weight polysaccharides from Grifola frondosa and the mechanism of their inhibitory effects on gastric cancer cells [J]. International Journal of Biological Macromolecules, 2024, 269:131812. [14] Ji Hai-Yu, Fan Yu-Ting, Long Yan, Dai Ke-Yao, Zheng Guo-Qiang, Jia Xiao-Yu, Liu An-Jun, Yu Juan. Structural analysis of Salvia miltiorrhiza polysaccharide and its regulatory functions on t cells subsets in tumor-bearing mice combined with thymopentin [J]. International Journal of Biological Macromolecules, 2024, 277:133832. [15] Yu Juan, Long Yan, Chi Jin-Yue, Dai Ke-Yao, Jia Xiao-Yu, Ji Hai-Yu*. Effects of ethanol concentrations on primary structural and bioactive characteristics of Dendrobium officinale polysaccharides [J]. Nutrients, 2024, 16(6):897. [16] Ji Hai-Yu, Fan Yu-Ting, Gao Xiao-Ji, Gong You-Shun, Dai Ke-Yao, Wang Zhen-Hua, Xu Bo, Yu Juan. The protective effects of water-soluble alginic acid on the n-terminal of thymopentin [J]. Molecules, 2023, 28(18), 6445. [17] Ji Hai-Yu, Lou Xiao-Wei, Jiao Jian-Shuang, Li Yang, Dai Ke-Yao, Jia Xiao-Yu. Preliminary structural characterization of selenium nanoparticle composites modified by Astragalus polysaccharide and the cytotoxicity mechanism on liver cancer cells [J]. Molecules, 2023, 28(4):1561. [18] Fan Yu-Ting, Long Yan, Gong You-Shun, Gao Xiao-Ji, Zheng Guo-Qiang, Ji Hai-Yu*. Systemic immunomodulatory effects of Codonopsis pilosula glucofructan on S180 solid-tumor-bearing mice [J]. International Journal of Molecular Sciences, 2023, 24(21), 15598. [19] Ji Hai-Yu, Yu Juan, Jiao Jian-Shuang, Dong Xiao-Dan, Yu Sha-Sha, Liu An-Jun. Ultrasonic-assisted extraction of Codonopsis pilosula glucofructan: optimization, structure, and immunoregulatory activity [J]. Nutrients, 2022, 14(5): 927. [20] Ji Hai-Yu, Dai Ke-Yao, Liu Chao, Yu Juan, Liu An-Jun, Chen Ye-Fu. The ethanol-extracted polysaccharide from Cynanchum paniculatum: optimization, structure, antioxidant and antitumor effects [J]. Industrial Crops and Products, 2022, 175: 114243. [21] Ji Hai-Yu, Dai Ke-Yao, Liu Chao, Yu Juan, Jia Xiao-Yu, Liu An-Jun. Preparation, antioxidant and immunoregulatory activities of a macromolecular glycoprotein from Salvia miltiorrhiza [J]. Foods, 2022, 11(5): 705. [22] Yu Juan, Dong Xiao-Dan, Jiao Jian-Shuang, Yu Sha-sha, Ji Hai-Yu*, Liu An-Jun*, Chen Ye*. Extraction, purification, and biological activities in vivo of a novel fructose-rich polysaccharide from Codonopsis pilosula [J]. Industrial Crops and Products, 2022, 176: 114309. [23] Yu Juan, Dong Xiao-Dan, Jiao Jian-Shuang, Yu Sha-sha, Ji Hai-Yu*, Liu An-Jun, Chen Ye. The inhibitory effects of selenium nanoparticles modified by fructose-enriched polysaccharide from Codonopsis pilosula on hepg2 cells [J]. Industrial Crops and Products, 2022, 176: 114335. [24] Ji Hai-Yu, Liu Chao, Dai Ke-Yao, Yu Juan, Liu An-Jun, Chen Ye-Fu. The immunosuppressive effects of low molecular weight chitosan on thymopentin-activated mice bearing H22 solid tumors [J]. International Immunopharmacology, 2021, 99: 108008. [25] Ji Hai-Yu, Liu Chao, Dai Ke-Yao, Yu Juan, Liu An-Jun, Chen Ye-Fu. The extraction, structure, and immunomodulation activities in vivo of polysaccharides from Salvia miltiorrhiza [J]. Industrial Crops and Products, 2021, 173: 114085. [26] Yu Juan, Dong Xiao-Dan, Jiao Jian-Shuang, Ji Hai-Yu*, Liu An-Jun*. Antitumor and immunoregulatory activities of a novel polysaccharide from Astragalus membranaceus on S180 tumor-bearing mice [J]. International Journal of Biological Macromolecules, 2021, 189: 930-938. [27] Yu Juan, Liu Chao, Ji Hai-Yu*, Liu An-Jun. The caspases-dependent apoptosis of hepatoma cells induced by an acid-soluble polysaccharide from Grifola frondosa [J]. International Journal of Biological Macromolecules, 2020, 159: 364-372. [28] Yu Juan, Ji Hai-Yu*, Liu Chao, Liu An-Jun. The structural characteristics of an acid-soluble polysaccharide from Grifola frondosa and its antitumor effects on H22-bearing mice [J]. International Journal of Biological Macromolecules, 2020, 158: 1288-1298. [29] Liu Chao, Ji Hai-Yu*, Wu Peng, Yu Juan, Liu An-Jun. The preparation of a cold-water soluble polysaccharide from Grifola frondosa and its inhibitory effects on mkn-45 cells [J]. Glycoconjugate Journal, 2020, 37(4): 413-422. [30] Ji Hai-Yu, Yu Juan, Liu An-Jun. Seleno-β-lactoglobulin (se-β-lg) induces mitochondria-dependant apoptosis in hepg2 cells [J]. Molecular Biology Reports, 2019, 46(5): 5025-5031. [31] Ji Hai-Yu, Yu Juan, Liu An-Jun. Structural characterization of a low molecular weight polysaccharide from Grifola frondosa and its antitumor activity in H22 tumor-bearing mice [J]. Journal of Functional Foods, 2019, 61: 103472. [32] Ji Hai-Yu, Yu Juan, Dong Xiao-Dan, Liu An-Jun. Preparation of soluble dietary fibers from Gracilaria lemaneiformis and its antitumor activity in vivo [J]. Journal of Food Measurement and Characterization, 2019, 13(2): 1574-1582. [33] Ji Hai-Yu, Yu Juan, Chen Xiao-Yu, Liu An-Jun. Extraction, optimization and bioactivities of alcohol-soluble polysaccharide from Grifola frondosa [J]. Journal of Food Measurement and Characterization, 2019, 13(3): 1645-1651. [34] Ji Hai-Yu, Dong Xiao-Dan, Yu Sha-sha, Yu Juan, Feng Ying-Ying, Liu An-Jun. Immunoregulatory activity of polysaccharides from Tanyang congou black tea on H22 tumor-bearing mice [J]. Journal of Food Measurement and Characterization, 2019, 13(2): 1620-1626. [35] Ji Hai-Yu, Chen Pei, Yu Juan, Feng Ying-Ying, Liu An-Jun. Effects of heat treatment on the structural characteristics and antitumor activity of polysaccharides from Grifola frondosa [J]. Applied Biochemistry and Biotechnology, 2019, 188(2): 481-490. [36] Yu Juan, Ji Hai-Yu, Yang Zhi-Zhi, Liu An-Jun. Relationship between structural properties and antitumor activity of Astragalus polysaccharides extracted with different temperatures [J]. International Journal of Biological Macromolecules, 2019, 124: 469-477. ● 主要专利 [1]于娟, 杨嘉靖, 雷坤, 胡海春, 杨秋柠, 路一晗, 毛德成, 纪海玉. 一种血红铆钉菇高分子多糖及其应用[P]. 山东省: CN121045408B, 2026-01-06. [2]纪海玉, 韩笑, 纪红菲, 杨秋柠, 毛德成, 路一晗, 韩冰, 于娟. 一种褐环乳牛肝菌木聚糖棕榈酸酯及其制备方法和应用[P]. 山东省: CN120795202B, 2025-12-12. [3]于娟, 龙艳, 杨嘉靖, 纪红菲, 韩笑, 范誉婷, 纪海玉. 铁皮石斛糖脂及其制备方法和抗氧化应用[P]. 山东省: CN119215121B, 2025-06-20. [4]纪海玉, 高小霁, 范誉婷, 纪红菲, 龙艳, 于娟. 一种褐环乳牛肝菌多糖及其制备方法和免疫调控应用[P]. 山东省: CN118420804B, 2024-08-30. ● 荣誉奖励 [1] 中国食品工业协会科学技术奖 二等奖 3/27 [2] 指导学生获奖：研究生国家奖学金，第九届全国大学生生命科学竞赛（科学探究类）三等奖，第十届全国大学生生命科学竞赛（科学探究类）省级三等奖 ● 联系方式 通信地址：山东省烟台市黄渤海新区四平路1号烟台大学八角湾校区 邮编：264005 Email：jihaiyu@ytu.edu.cn; haiyu11456@163.com |
