孟冬冬  博士/教授  

硕士生导师

●学习工作经历

2022年08月-至今：烟台大学，生命科学学院，副教授、教授

2020年7月-2022年8月：中国科学院天津工业生物技术研究所，副研究员

2016年2月-2020年7月：中国科学院天津工业生物技术研究所，助理研究员

2011年09月-2015年07月：中国科学院青岛生物能源与过程研究所，生物化学与分子生物学专业，博士研究生

2008年09月-2011年07月：齐鲁工业大学，生物化工专业，硕士研究生

2004年09月-2008年07月：山东建筑大学，生物工程专业，本科生

●主讲课程

《生物分离工程》、《生物工程专业导论》

● 研究方向

以酶催化为研究核心，涉及酶学、合成生物学、分子生物学、微生物学等方面，开展食品功能成分、医药保健品、高值化学品等的绿色生物制造。研究方向包括：

1. 生物催化转化：基于“基因-酶-反应”的功能产品生物制造

2. 合成生物学：多酶分子机器、酶元件集成、系统适配、多酶复合体

3. 酶与酶工程：酶资源挖掘、酶学表征、酶定向进化

● 主持教学、科研项目

[1] 国家自然科学基金面上项目，50万元，2026-2029，在研，主持

[2] 山东省自然科学基金面上项目，10万元，2024-2026，在研，主持

[3] 烟台大学青年博士科研基金项目，20万元，2023-2025，结题，主持

[4] 企业委托横向课题，30万元，2023-2025，结题，主持

[5] 国家重点研发计划“绿色生物制造”重点专项，100万元，2021-2024，结题，子课题负责人

[6] 国家自然科学基金青年基金，21万元，2017-2019，结题，主持

● 主要论文、专著与专利

第一作者及通讯作者论文

[1] Guimeng Xiao, Xiaonan Zhao, Shaoyun Shi, Jianxing Lu, Guiling Li, Fengying Gong, Xinming Feng*, Juanjuan Liu*, and Dongdong Meng*. Thermostable Whole-Cell Biocatalysts Enable Sustainable and Practical Synthesis of N‑Acetylneuraminic Acid. Journal of Agricultural and Food Chemistry. 2026. 74, 1144−1153.

[2] Wenyong Wang#, Juanjuan Liu#, Shiwen Xu, Chao Yuan*, Dongdong Meng*. Unraveling the substrate specificity of a thermostable and highly active isoamylase for one-pot starch upgrading via enzymatic cascade. Biochemical Engineering Journal. 2026. 230: 110145.

[3] Zihan Cheng#, Juanjuan Liu#, Zixuan Huang, Jianyu Wang, Chao Yuan*, Dongdong Meng*. Upgrade of sucrose to glucosyl glycerate and mannitol by a thermostable and minimized three-enzyme cascade. Biochemical Engineering Journal. 2026. 226: 109983.

[4] Juanjuan Liu, Guangpeng Xu, Likun Liang, Dongdong Meng*. Sugar phosphatases as biocatalysts for biomanufacturing: Recent advances and applications. Biotechnology Advances. 2025. 82: 108596. 1区，IF=12.5

[5] Xinming Feng#, Xinyu Cui#, Kun Wang, Juanjuan Liu, Dongdong Meng*. Enzymatic characterization of a thermostable 6‑phosphogluconate dehydrogenase from Hydrogenobacter thermophilus and its application for NADH regeneration. 3 Biotech. 2025. 15: 3.

[6] Juanjuan Liu#, Mengfei Ren#, Haoran Ma, Huilin Zhang, Xinyu Cui, Runyuan Kang, Xinming Feng, Dongdong Meng*. One-pot sustainable synthesis of glucosylglycerate from starch and glycerol through artificial in vitro enzymatic cascade. Bioresource Technology. 2024. 399: 130611.

[7] Juanjuan Liu#, Runyuan Kang#, Xinyue Yang, Hanhan Xie, Xinyu Cui, Mengfei Ren, Xinming Feng*, Dongdong Meng*. Sustainable cellobionic acid biosynthesis from starch via artificial in vitro synthetic enzymatic biosystem. International Journal of Biological Macromolecules. 2024. 260: 129641.

[8]  Juanjuan Liu#, Xinming Feng#, Likun Liang, Liqin Sun*, Dongdong Meng*. Enzymatic biosynthesis of D-galactose derivatives: Advances and perspectives. International Journal of Biological Macromolecules. 2024. 267: 131518.

[9] Dongdong Meng#, Meixia Liu#, Hao Su*, Haiyan Song, Lijie Chen, Qiangzi Li, Ya-nan Liu, Zhiguang Zhu, Weidong Liu, Xiang Sheng, Chun You*, Yi-Heng P. Job Zhang. Coenzyme engineering of glucose-6-phosphate dehydrogenase on a nicotinamide-based biomimic and its application as a glucose biosensor. ACS Catalysis. 2023. 13: 1983–1998. 1区，IF=13.7

[10] Lijie Chen, Yanmei Qin, Long Ma, Dongdong Meng*, Chun You*. Biosynthesis of Lacto-N-biose I from starch and N-acetylglucosamine via an in vitro synthetic enzymatic biosystem. Synthetic and Systems Biotechnology. 2023. 8: 555–562.

[11] Qiangzi Li#, Dongdong Meng#, Chun You*. An artificial multi-enzyme cascade biocatalysis for biomanufacturing of nicotinamide mononucleotide from starch and nicotinamide in one-pot. Enzyme and Microbial Technology. 2022. 162: 110122.

[12] Dongdong Meng, Xinlei Wei, Xue Bai, Wei Zhou, Chun You*. Artificial in vitro synthetic enzymatic biosystem for the one-pot sustainable biomanufacturing of glucosamine from starch and inorganic ammonia. ACS Catalysis. 2020. 10: 13809-13819. 1区，IF=13.7

[13] Dongdong Meng*, Juan Wang, Chun You*. The properties of the linker in a mini-scaffoldin influence the catalytic efficiency of scaffoldin-mediated enzyme complexes. Enzyme and Microbial Technology. 2020. 133: 109460.

[14] Dongdong Meng, Ranran Wu, Juan Wang, Zhiguang Zhu*, Chun You*. Acceleration of cellodextrin phosphorolysis for bioelectricity generation from cellulosic biomass by integrating a synthetic two-enzyme complex into an in vitro synthetic enzymatic biosystem. Biotechnology for Biofuels. 2019. 12(1): 267.

[15] Dongdong Meng, Ailing Liang, Xinlei Wei, Chun You*. Enzymatic characterization of a thermostable phosphatase from Thermomicrobium roseum and its application for biosynthesis of fructose from maltodextrin. Applied Microbiology and Biotechnology. 2019. 103(15): 6129-6139.

[16] Dongdong Meng, Xinlei Wei, Yi-Heng P. Job Zhang, Zhiguang Zhu, Chun You*, Yanhe Ma. Stoichiometric conversion of cellulosic biomass by in vitro synthetic enzymatic biosystems for biomanufacturing. ACS Catalysis. 2018. 8: 9550-9559. 1区，IF=13.7

[17] Dongdong Meng#, Xi Liu#, Sheng Dong#, Ye-Fei Wang, Xiao-Qing Ma, Haixia Zhou, Xinquan Wang, Li-Shan Yao, Yingang Feng*, and Fu-Li Li*. Structural insights into the substrate specificity of a glycoside hydrolase family 5 lichenase from Caldicellulosiruptor sp. F32. Biochemical Journal. 2017. 474(20): 3373-3389.

[18] Dongdong Meng, Bing Wang, Xiao-Qing Ma, Shi-Qi Ji, Ming Lu, Fu-Li Li*. Characterization of a thermostable endo-1,3(4)-beta-glucanase from Caldicellulosiruptor sp strain F32 and its application for yeast lysis. Applied Microbiology and Biotechnology. 2016. 100(11): 4923-4934.

[19] Dongdong Meng, Yu Ying, Kun-Di Zhang, Ming Lu, Fu-Li Li. Depiction of carbohydrate-active enzyme diversity in Caldicellulosiruptor sp. F32 at the genome level reveals insights into distinct polysaccharide degradation features. Molecular Biosystems. 2015. 11: 3164-3173.

[20] Dongdong Meng, Yu Ying, Xiao-Hua Chen, Ming Lu, Kang Ning, Lu-Shan Wang and Fu-Li Li. Distinct Roles for Carbohydrate-Binding Modules of Glycoside Hydrolase 10 (GH10) and GH11 Xylanases from Caldicellulosiruptor sp. Strain F32 in Thermostability and Catalytic Efficiency. Applied and Environmental Microbiology. 2015. 81: 2592-2601.

专利

[1] 孟冬冬; 刘娟娟; 任梦菲; 一种酶催化制备葡萄糖基甘油酸的方法, 2024, 中国, 202410496618.5

[2] 孟冬冬; 刘娟娟; 一种切除麦芽糊精支链的酶及其构建和应用, 2024, 中国, 2024111792402

[3] Chun You; Dongdong Meng; Enzymatic preparation of glucosamine, 2024, 美国, 17260168

[4] 游淳; 孟冬冬; 周伟; 一种耐热6-磷酸氨基葡萄糖磷酸酶突变体及其应用, 2023, 中国, 201911408177.4

[5] 游淳; 孟冬冬; 一种仿生辅酶偏好性的葡萄糖6-磷酸脱氢酶突变体及其应用, 2023, 中国, 201911376254.2

[6] 游淳; 孟冬冬; 一种纤维素完全磷酸解产肌醇的方法, 2022, 中国, 201810972707.7

[7] 游淳; 孟冬冬; 氨基葡萄糖的酶法制备, 2018, 中国, 201810772487.3

● 联系方式

通信地址：山东省烟台市黄渤海新区四平路1号，烟台大学生命科学学院

Email：mengdd@ytu.edu.cn