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高永林 博士

教授,硕士生导师

2010.8-至今:烟台大学,生命科学学院,讲师/副教授/教授

教育经历

2007.9-2010.7:中国海洋大学,博士

2000.09-2003.07: 贵州大学, 硕士

1996.09-2000.07: 内蒙古农业大学, 学士

主讲课程

本科生课程:《功能性食品学》、《人体及动物生理学》

研究生课程:《功能性食品开发与应用》

研究方向

[1] 功能性食品研究与开发

[2] 食品毒理学及GRAS认证评估

[3] 海洋生物资源开发和高值化利用

主持科研项目

[1] RD产品开发研究,2020-2022,68万元。

[2] YLS复合蛋白肽固体饮料项目开发,2020-2023,50万元。

[3] 海洋多糖MTR-19项目开发研究,2019-2021,40万元。

[4] 海洋多肽功能产品系列开发,2015-2018,66万元。

[5] 海藻酸钠鱼皮胶原纤维水凝胶生物活性评价, 2019-2020,15万元。

[6] 液体创口敷料新材料开发研究,2019-2022,63万元。

主要论文(第1作者/通讯作者)

[1] Wang J, Qin S, Lin J, Wang Q, Li W, Gao Y*. Phycobiliproteins from microalgae: research progress in sustainable production and extraction processes.Biotechnol Biofuels Bioprod,2023;16(1):170.

[2] Gao Y, Liu P, Wang D, Liu J, Yang L, Kang Y, Han B, Yin J, Zhu J, Wang K, Li C*.Isolation and characterization of a novel protein from Momordica charantia L. Positively regulates lipid metabolism activity in vivo and in vitro. J Funct Foods, 96 (2022) 105218.

[3] Gao Y, Kang Y,Tong Wang T, Li C, Shen S, Qu C, Gong S, Liu P, Yang L, Liu J, Han B, Li C*. Alginate microspheres-collagen hydrogel, as a novel 3D culture system, enhanced skin wound healing of hUCMSCs in rat model. Colloids Surf B Biointerfaces,2022;219:112799.

[4] Li D, Wang T, Zhao J, Wu J, Zhang S, He C, Zhu M, El-Newehy, El-Hamshary M, Morsi Y, Gao Y*, Mo X*. Prodrug inspired bi-layered electrospun membrane with properties of enhanced tissue integration for guided tissue regeneration. J Biomed Mater Res B Appl Biomater. 2022;110(9):2050-2062.[5] Yang L, Chen K, Liu P, Kang Y, Shen S, Qu C, Gong S, Liu Y, Gao Y*. Preparation of Nile tilapia skin collagen powder by low-temperature and comprehensive evaluation of hemostasis and wound healing. Int J Artif Organs. 2023;46(2):99-112.

[6] 王通, 王广飞, 张淑敏, 曲承蕾, 李诚博, 高永林*.基于天然多糖的水凝胶伤口敷料的研究进展. 材料导报.2022年,32卷,6期,182-190.

[7] Gao Y, Chen X, Li C, Wang H, Tian J*, Fu F*.Toxicological evaluation of, red rice yeast extract, Xuezhikang: Acute, 26-week chronic and genotoxicity studies. Regul Toxicol Pharmacol. 2020;9:104654.

[8] Li C, Wang Z, Li G, Wang Z, Yang J, Li Y, Wang H, Jin H, Qiao J, Wang H, Tian J, Lee W, Gao Y*. Acute and repeated dose 26-week oral toxicity study of 20(S)- ginsenoside Rg3 in Kunming mice and Sprague-Dawley rats. J Ginseng Res. 2020;44(2):222-228.

[9] Gao Y, Wang G, Wang T, Li G, Lin J, Sun L, Wu X, Sun X, Wang H, Li C, Tian J, Zhu J, Wang K, Cho S.A 26-week 20(S)-ginsenoside Rg3 oral toxicity study in Beagle dogs. Regul Toxicol Pharmacol. 2020;110:104522.

[10] Li C, Wang Z, Wang T, Wang G, Li G, Sun C, Lin J, Sun L, Sun X, Cho S, Wang H, Gao Y*, Tian J.Repeated-dose 26-week oral toxicity study of ginsenoside compound K in Beagle dogs. J Ethnopharmacol. 2020;248:112323.

[11] Gao Y, Wang T, Wang G, Li G, Sun C, Jiang Z, Yang J, Li Y, You Y, Wu X, Sun L, Wang H, Li C, Tian J, Zhu J, Wang K, Cho S. Preclinical safety of ginsenoside compound K: Acute, and 26-week oral toxicity studies in mice and rats. Food Chem Toxicol. 2019;131:110578.

[12] Guo W, Gao Y#, Jiang W, Li C, Lin F, Zhu H, Wang H, Ye L, Qi J, Cen X, Tian J . Toxicity effects of a novel potent triple reuptake inhibitor, LPM570065, on the fertility and early embryonic development in Sprague-Dawley rats. Regul Toxicol Pharmacol. 2018;100:45-51.

[13] Gurung R, Kim D, Kim L, Lee A, Wang Z, Gao Y*. Toxicological evaluation of 6'-sialyllactose (6'-SL) sodium salt. Regul Toxicol Pharmacol. 2018;95:182-189.

[14] Gao Y, Wang Y, Wang K, Zhu J, Li G, Tian J, Li C, Wang Z, Li J, Lee A, Guo C. Acute and a 28-day repeated-dose toxicity study of total flavonoids from Clinopodium chinense (Benth.) O. Ktze in mice and rats. Regul Toxicol Pharmacol. 2017;91:117-123.

[15] Gao Y, Li C, Wang Y, Liu Y, Li G, Fan X, Li Y, Tian J, Lee AW. Nonclinical safety of astilbin: A 4-week oral toxicity study in rats with genotoxicity, chromosomal aberration, and mammalian micronucleus tests. Food Chem Toxicol.2017;107(Pt A):1-9.[16] Li C, Han R, Kang L, Wang J, Gao Y*, Li Y, He J,Tian J. Pirfenidone controls the feedback loop of the AT1R/p38 MAPK/ renin-angiotensin system axis by regulating liver X receptor-α in myocardial infarction-induced cardiac fibrosis. Sci Rep. 2017, 40523.

[17] Gao Y, Li C, Xiao L, Jiang Z, Li Y, Susan C, Lee.W. Repeated sub-chronic oral toxicity study of xylooligosaccharides (XOS) in dogs. Regul Toxicol Pharmacol. 2017;86:379-385.

[18] Li C,Gao Y*,WangY, Li G, Fan X, Li Y, Guo C, Tao J. Genotoxicity testing of sodium formononetin-3'-sulphonate (Sul-F) by assessing bacterial reverse mutation, chromosomal aberrations and micronucleus tests. Regul Toxicol Pharmacol. 2017;86:374-378.

[19] Li C, Li G, Sun C, Wang X, Gao Y*. A 90-day subchronic toxicity study with Sodium formononetin-3'-sulphonate (Sul-F) delivered to dogs via intravenous administration. Regul Toxicol Pharmacol. 2016;77:87-92.

[20] Gao Y, Kang L, Li C, Wang X, Sun C, Li Q, Liu R, Wang J. Resveratrol ameliorates diabetes-induced cardiac dysfunction through AT1R-ERK/p38 MAPK signaling pathway. Cardiovasc Toxicol. 2016;16(2):130-7.

[21] Li G, Yang M, Hao X, Li C, Gao Y*, Tao J.  Acute toxicity of sodium formononetin-3'-sulphonate (Sul-F) in Sprague- Dawley rats and Beagle dogs. Regul Toxicol Pharmacol. 2015;73(2):629-33.

[22] Gao Y, Li C, Kang L, Hang B, Yan M, Li S, Jin H, Lee A, Susan C. Subchronic toxicity study, preceded by an in utero exposure phase, with refined arachidonic acid-rich oil (RAO) derived from Mortierella alpine XM027 in rats. Regul Toxicol Pharmacol. 2014;70(3):696-703.

[23] Gao Y, Shen J, Yin,J, Li C, Fu C, Susan C. A subchronic dietary toxicity study of rice hull fiber in rats. Food Chem Toxicol. 2013;51:137-42.

[24] Gao Y, Li C, Yin J , Shen J, Wang H, Wu Y, Jin H. Fucoidan, a sulfated polysaccharide from brown algae, improves cognitive impairment induced by infusion of amyloid-β peptide in rats. Environ Toxicol Phar. 2012, 33(2):304-11.

[25] Gao Y, Dong C, Yin J, Shen J, Tian J, Li C. Neuroprotective effect of fucoidan on H2O2-induced apoptosis in PC12 Cells via activation of PI3K/Akt Pathway. Cell Mol Neurobiol. 2012, 32(4):523-9.

[26] Gao Y, Zhang S, Li C, Xiao L, Shen J, Yin J. Acute and subchronic toxicity of Xylo-oligosaccharide in mice and rats. Toxicol Mech Methods. 2012;22(8):605-10.

[27] Gao Y, Jiang W, Dong C, Li C, Fu X, Li M, Tian J, Jin H, Shen J. Anti-inflammatory effects of sophocarpine in LPS-induced RAW 264.7 cells via NF-κB and MAPKs signaling pathways. Toxicol in Vitro. 2012; 26(1):1-6.

[28] Li C, Gao Y*, Tian J, Xing Y, Zhu H, Shen J. Long-term oral Asperosaponin VI attenuates cardiac dysfunction, myocardial fibrosis in a rat model of chronic myocardial infarction. Food Chem Toxicol. 2012;50(5):1432-8.

[29] Gao Y, Liu Z, Li C, Shen J, Yin H, Li G. Subchronic toxicity studies with ginsenoside compound K delivered to dogs via intravenous administration. Food Chem Toxicol. 2011,49 (8):1857-62.

[30] Gao Y, Li C, Shen J, Yin H, An X, Jin H. Effect of food azo dye tartrazine on learning and memory functions in mice and rats, and the possible mechanisms involved. J Food Sci. 2011;76(6): T125–T129.

[31] Li C, Gao Y*, Xing Y, Zhu H, Shen J, Tian J. Fucoidan, a sulfated polysaccharide from brown algae, against myocardial ischemia–reperfusion injury in rats via regulating the inflammation response. Food Chem Toxicol. 2011, 49(9):2090-5.

学术/社会兼职

2021年受聘首届驻烟高校院所高层次人才产学研合作科创人才顾问”。

邮箱

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