纪海玉  博士/讲师

●出生年月

1990年1月

●工作经历

2022年06月~至今：烟台大学，生命科学学院，助理研究员，讲师

●学习经历

2020年07月~2022年06月：天津科技大学，生物工程学院，轻工技术与工程科研流动站，制糖工程专业，博士后，助理研究员

2017年09月~2020年06月：天津科技大学，食品科学与工程学院，食品科学专业，博士研究生

2015年05月~2017年07月：天津科技大学，食品科学与工程学院，科研助理

2012年09月~2015年03月：天津科技大学，食品科学与工程学院，食品科学专业，硕士研究生

2008年09月~2012年07月：山西农业大学，食品科学与工程学院，生物工程专业，本科生

●主讲课程

本科生课程：

研究生课程：

● 研究方向

主要从事天然产物结构功能方面的研究，研究方向包括：

1. 天然多糖、蛋白的提取、纯化、结构鉴定

2. 自然衰老致机体多糖、蛋白的流失机制

3. 天然产物的抗肿瘤、免疫调节、抗衰老活性评价

● 教学、科研项目

[1] 溶剂电位对龙须菜琼胶多糖结构表征及成膜特性的影响机制研究，烟台大学青年博士科研基金，20万元，1/1，2022-2027，在研，主持。

[2] 天然白芨多糖基保鲜材料的可控构建及其在桃果实保鲜中的应用，2021年度农业农村部农产品贮藏保鲜重点实验室开放基金，5万元，1/4，2020-2022，在研，主持。

[3] 亚硒酸化β-乳球蛋白真空氧化还原导入机制及其抗衰老机理研究，国家自然科学基金，82万元，2012-2017，结题，参与。

[4] 食品专用蛋白基料制备关键技术研究与开发，国家高技术研究计划（863），776万元，2012-2017，结题，参与。

[5] 抗氧化功能食品开发，横向项目，30万，2019-2022，结题，参与。

● 主要论文

[1] Ji Hai-Yu, Yu Juan, Jiao Jian-Shuang, Dong Xiao-Dan, Yu Sha-Sha, Liu An-Jun. Ultrasonic-Assisted Extraction of Codonopsis pilosula Glucofructan: Optimization, Structure, and Immunoregulatory Activity [J]. Nutrients, 2022, 14(5): 927. SCI 2区

[2] Ji Hai-yu, Dai Ke-yao, Liu Chao, Yu Juan, Liu An-jun, Chen Ye-fu. The ethanol-extracted polysaccharide from Cynanchum paniculatum: Optimization, structure, antioxidant and antitumor effects [J]. Industrial Crops and Products, 2022, 175: 114243. SCI 1区

[3] Ji Hai-Yu, Dai Ke-Yao, Liu Chao, Yu Juan, Jia Xiao-Yu, Liu An-Jun. Preparation, Antioxidant and Immunoregulatory Activities of a Macromolecular Glycoprotein from Salvia miltiorrhiza [J]. Foods, 2022, 11(5): 705. SCI 2区

[4] Ji Hai-yu, Liu Chao, Dai Ke-yao, Yu Juan, Liu An-jun, Chen Ye-fu. The immunosuppressive effects of low molecular weight chitosan on thymopentin-activated mice bearing H22 solid tumors [J]. International Immunopharmacology, 2021, 99: 108008. SCI 2区

[5] Ji Hai-yu, Liu Chao, Dai Ke-yao, Yu Juan, Liu An-jun, Chen Ye-fu. The extraction, structure, and immunomodulation activities in vivo of polysaccharides from Salvia miltiorrhiza [J]. Industrial Crops and Products, 2021, 173: 114085. SCI 1区

[6] Ji Hai-yu, Yu Juan, Liu An-jun. Seleno-β-lactoglobulin (Se-β-Lg) induces mitochondria-dependant apoptosis in HepG2 cells [J]. Molecular Biology Reports, 2019, 46(5): 5025-5031. SCI 3区

[7] Ji Hai-yu, Yu Juan, Liu An-jun. Structural characterization of a low molecular weight polysaccharide from Grifola frondosa and its antitumor activity in H22 tumor-bearing mice [J]. Journal of Functional Foods, 2019, 61: 103472. SCI 2区

[8] Ji Hai-yu, Yu Juan, Dong Xiao-dan, Liu An-jun. Preparation of soluble dietary fibers from Gracilaria lemaneiformis and its antitumor activity in vivo [J]. Journal of Food Measurement and Characterization, 2019, 13(2): 1574-1582. SCI 3区

[9] Ji Hai-yu, Yu Juan, Chen Xiao-yu, Liu An-jun. Extraction, optimization and bioactivities of alcohol-soluble polysaccharide from Grifola frondosa [J]. Journal of Food Measurement and Characterization, 2019, 13(3): 1645-1651. SCI 3区

[10] Ji Hai-yu, Dong Xiao-dan, Yu Sha-sha, Yu Juan, Feng Ying-ying, Liu An-jun. Immunoregulatory activity of polysaccharides from Tanyang Congou black tea on H22 tumor-bearing mice [J]. Journal of Food Measurement and Characterization, 2019, 13(2): 1620-1626. SCI 3区

[11] Ji Hai-yu, Chen Pei, Yu Juan, Feng Ying-ying, Liu An-jun. Effects of Heat Treatment on the Structural Characteristics and Antitumor Activity of Polysaccharides from Grifola frondosa [J]. Applied Biochemistry and Biotechnology, 2019, 188(2): 481-490. SCI 3区

[12] 纪海玉,冯莹莹,于娟,彭雪丽,董晓丹,刘安军.HepG2细胞滚瓶培养工艺优化及硒酸壳聚糖对其抑制作用[J].食品研究与开发,2018,39(03):189-195. 北大中文核心

[13] Yu Juan, Dong Xiao-dan, Jiao Jian-shuang, Yu Sha-sha, Ji Hai-yu*, Liu An-jun*, Chen Ye*. Extraction, purification, and biological activities in vivo of a novel fructose-rich polysaccharide from Codonopsis pilosula [J]. Industrial Crops and Products, 2022, 176: 114309. SCI 1区

[14] Yu Juan, Dong Xiao-dan, Jiao Jian-shuang, Yu Sha-sha, Ji Hai-yu*, Liu An-jun, Chen Ye. The inhibitory effects of selenium nanoparticles modified by fructose-enriched polysaccharide from Codonopsis pilosula on HepG2 cells [J]. Industrial Crops and Products, 2022, 176: 114335. SCI 1区

[15] Yu Juan, Dong Xiao-dan, Jiao Jian-shuang, Ji Hai-yu*, Liu An-jun*. Antitumor and immunoregulatory activities of a novel polysaccharide from Astragalus membranaceus on S180 tumor-bearing mice [J]. International Journal of Biological Macromolecules, 2021, 189: 930-938. SCI 1区

[16] Yu Juan, Liu Chao, Ji Hai-yu*, Liu An-jun. The caspases-dependent apoptosis of hepatoma cells induced by an acid-soluble polysaccharide from Grifola frondosa [J]. International Journal of Biological Macromolecules, 2020, 159: 364-372. SCI 2区

[17] Yu Juan, Ji Hai-yu*, Liu Chao, Liu An-jun. The structural characteristics of an acid-soluble polysaccharide from Grifola frondosa and its antitumor effects on H22-bearing mice [J]. International Journal of Biological Macromolecules, 2020, 158: 1288-1298. SCI 2区

[18] Liu Chao, Ji Hai-yu*, Wu Peng, Yu Juan, Liu An-jun. The preparation of a cold-water soluble polysaccharide from Grifola frondosa and its inhibitory effects on MKN-45 cells [J]. Glycoconjugate Journal, 2020, 37(4): 413-422. SCI 3区

[19] Yu Juan1, Ji Hai-yu1, Yang Zhi-zhi, Liu An-jun. Relationship between structural properties and antitumor activity of Astragalus polysaccharides extracted with different temperatures [J]. International Journal of Biological Macromolecules, 2019, 124: 469-477. SCI 2区

[20] Yu Juan1, Ji Hai-yu1, Dong Xiao-dan, Feng Ying-ying, Liu An-jun. Apoptosis of human gastric carcinoma MGC-803 cells induced by a novel Astragalus membranaceus polysaccharide via intrinsic mitochondrial pathways [J]. International Journal of Biological Macromolecules, 2019, 126: 811-819. SCI 2区

[21] Zheng Guo-Qiang1, Ji Hai-Yu1, Zhang Shao-Jing, Yu Juan, Liu An-Jun. Selenious-β-lactoglobulin induces the apoptosis of human lung cancer A549 cells via an intrinsic mitochondrial pathway [J]. Cytotechnology, 2018, 70(6): 1551-1563. SCI 4区

[22] Zhang Yan1, Ji Hai-yu1, Yu Juan1, Zhang Zi. Effect of Cold and Heat Shock Treatment on the Color Development of Mature Green Tomatoes and the Roles of Their Antioxidant Enzymes [J]. Food and Bioprocess Technology, 2018, 11(3): 705-709. SCI 2区

[23] Zhang Yan1, Ji Hai-yu1, Yu Juan1. Aromatic constituents and their changes of Illicium verum processed by different heating methods [J]. Industrial Crops and Products, 2018, 118: 362-366. SCI 2区

[24] Sun Su-jun1, Ji Hai-yu1, Feng Ying-ying, Kang Yu, Yu Juan, Liu An-jun. A novel mechanism of tumor-induced thymic atrophy in mice bearing H22 hepatocellular carcinoma [J]. Cancer Management and Research, 2018, 10: 417-424. SCI 2区

● 荣誉奖励

● 联系方式

通信地址：山东省烟台市莱山区清泉路30号，烟台大学生命科学学院

邮编：264005

Email：jihaiyu@ytu.edu.cn; haiyu11456@163.com